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Elderly the aging process is characterized by changes in body composition, renal function, and hepatic function that reduce ones functional reserve leading to prolonged plasma elimination half-life Frequency of use people who take Vyvanse more often will eliminate the drug slower than those who take it less often The dose of the drug taken the higher the dose one takes, the longer it will stay in ones system Other drugs being taken Vyvanse drug interactions can result in longer detection times The factors discussed above are only but a part of a long list of factors that may affect how long drugs such as Lisdexamfetamine dimesylate will stay in the system