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The sites can be formed when certain relatively unstable DNA adducts, such as 7-methyldeoxyguanosine, lose their purine base (in this case 7-methylguanine) due to spontaneous decomposition or hydrolysis

Science 186 , 265267 (1974)

"Environmental tobacco smoke exposure and ischaemic heart disease: an evaluation of the evidence"

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If not on medication, subjects were to have experienced a major depressive episode in the past 2 years, which was successfully treated