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In the 1960s and '70s, Salem advertised its cigarettes as "Springtime Fresh." Not only did this comparison to springtime provide Salem with the perfect excuse to apply green landscapes to its advertisements (reflecting minty green menthol flavor), but, more importantly, it also served as a means of subliminally aligning Salem cigarettes with vitality

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Availability of data and materials Data are available on Open Science Framework ( with age provided in bands to preserve anonymity

Heartburn affects over 60 million Americans at least once every month (x)

Phenotypes and Endophenotypes: Foundations for Genetic Studies of Nicotine Use and Dependence

These devices require no assembly or maintenance, making them a convenient option for those new to vaping