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First-time prescriptions of AOM tirzepatide also did not increase from November to December 2024, likely due to the holidays

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Cons: Limited maximum weight loss, highly dependent on willpower, slow results

Why that selectivity exists at the receptor level isnt entirely settled it may reflect biased agonism, where the specific binding geometry favors the somatotroph signaling pathway over the corticotroph one, even though both cell populations express GHSR-1a

At the moment, GLP-1 usage poses a minimal impact to snacking sales, especially in comparison to broader macroeconomic issues like volatile inflation in parts of Europe, high costs-of-living, and compliance costs among others, Quash explains