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The researchers found that the severity of cigarette addiction, as indicated by the number of criteria met, increased with the frequency of smoking, with 35% of those smoking one-to-four cigarettes per day and 74% of those smoking 21 cigarettes or more per day being moderately or severely addicted

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PMC 10473173

doi:10.2105/AJPH.2019.305436

A loss of NOD2 function is a key event in the pathogenesis of ileal CD, since defective NOD2 leads to an increase in inflammation due to impaired bacterial clearance (36)