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Nutrients 10 (12), 1836

Oxyntomodulin is a biased agonist relative to GLP-1 1,3 (and exendin-P5 26 ), with a bias towards arrestin recruitment over cAMP production, which would compete for G protein interactions and may contribute to the lack of correlation between the faster G s dissociation and enhanced efficacy when assessing cAMP accumulation in whole cells over an extended timeframe

Moreover, as shown by our transient transfection of nave protoplasts, OSER structures are formed upon sudden expression waves of the membrane-bound G6PD5 proteoforms

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