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Molecular underpinnings of induced degenerative heterogeneity in the retinal pigment epithelium by Krishna Kumar Singh, Yang Jin, Ming-Wen Hu, Isabella Palazzo, Marisol Cano, Thanh Hoang, Imran Bhutto, Shusheng Wang, Debasish Sinha, Seth Blackshaw, Jiang Qian, and James T

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First, glycolysis alone is not sufficient to cover the metabolic demand of RPE cells, and second, RPE cells would metabolize far more glucose to fuel their own glycolysis, which would lead to a glucose shortage in glucose-dependent photoreceptor cells