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All were determined in the presence of bound antagonist or inverse agonist, and in the absence of associated G protein, so likely represent inactive conformations

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The semaglutide group had a 0.33 percentage point reduction in HbA1c ( P = .034), a 0.37 mmol/L decrease in total cholesterol ( P = .04) and a 0.29 mmol/L decline in LDL cholesterol ( P = .05) from baseline to 1 year

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