Synthesis and release of LH is under control of the hypothalamus through gonadotropin-releasing hormone (GnRH) and inhibited by testosterone via a negative feedback mechanism [Figure 2A] (9).The biosynthetic conversion of cholesterol to testosterone involves several discrete steps, of which the first one includes the transfer of cholesterol from the outer to the inner mitochondrial membrane by the steroidogenic acute regulatory protein (Star) and the subsequent side chain cleavage of cholesterol by the enzyme P450scc (10)
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Subjects completed a third test session following the four weeks of GPLC supplementation using the same testing protocol
namely, maximal (1 M agonist) cAMP production increased as maximal internalization fell, but reached a plateau beyond which further decrease in internalization did not yield additional increase in cAMP efficacy
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