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William Thomas Cain / Getty Images Kate Spade Spade revolutionized fashion in the early 1990s with her signature chic, boxy handbag that appealed to modern career women

Both products have been marketed as harm reduction tools, claiming to be safer alternatives to smoking cigarettes

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He said he uses gloves and safety goggles while handling it and stores it high up in a closet to keep it away from his dogs

The most frequently reported outcomes were smoking prevalence (165 studies), quit rate (126), quit attempt (107), quit intention (54) and tobacco sales (27)

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