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EC use was attributed to epithelial barrier damage in capillary endothelial cells and lung epithelial cells ( The production of ROS by EC, paired with the reduction of cellular glutathione levels, suggests that dual users may be subjected to higher levels of oxidative stress than single-substance users

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Methods All animal study protocols were reviewed and approved by the Institutional Animal Care and Use Committees at the Huntington Medical Research Institutes, and the University of California, Irvine