Despite the high prevalence of CUD and its negative consequences, there are currently no FDA-approved medications
Titration schedules in phase 3 trials of long acting insulin analogues incorporated individualization to allow the clinician to increase the dose to achieve optimal benefit without causing hypoglycaemia ( The oral obesity medications The oral GLP-1 based agents approved for obesity treatment deliver substantial weight loss
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The safety and efficacy of oral tretinoin in infants have not been established
Lagan AS, Rossetti P, Buscema M, La Vignera S, Condorelli RA, Gullo G, et al
(2026, Clinical Obesity) reviewed six studies covering 480,825 adults on GLP-1 medications and found that nutritional deficiencies are common vitamin D deficiency hit 13.6% at 12 months, iron depletion was frequent (2630% lower ferritin vs comparators), and B vitamin deficiencies rose steadily over treatment