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The National Cancer Institutes comprehensive review of light and low-tar cigarettes [50] concluded that Epidemiological and other scientific evidence, including patterns of mortality from smoking-caused diseases, does not indicate a benefit to public health from changes in cigarette design and manufacturing over the last 50 years. Under the 2009 U.S

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Main Outcome Measures Loss of autonomy over tobacco as measured by the Hooked on Nicotine Checklist, and tobacco dependence as defined in International Classification of Diseases, 10th Revision ( ICD-10 )

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