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The risks are much higher than 1.17 times of oropharyngeal cancer and 1.30 times of esophageal cancer in previous meta-analysis 43

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The risk assessment details: location, topic being assessed, description and evidence of impacts and potential impacts, an assessment of the severity of risk, and recommendations for corrective action

CSC increased VEGF and HIF-1 expression over a time course similar to that of the inflammatory cytokines, with maximal VEGF and HIF-1 mRNA levels being approximately two-fold (VEGF) and nine-fold (HIF-1) higher than those of the controls by 24 h (Fig