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That finding suggests high-dose GLP-1 medications could potentially reach the joints and influence inflammation directly, not just help through weight loss

A 90kg researcher who tolerates 4mg easily might escalate to 8mg sooner than a 60kg researcher who experiences significant appetite suppression at 4mg

Note: Metformin has not been approved by FDA for these uses, but there are multiple studies that have demonstrated the potential effectiveness of Metformin towards these benefits (see below)

Vitamin C has been shown to increase interferon production in vitro (17)

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