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Rolling Stone called his performance "almost unintelligible"

The absence of nicotine disrupts the brains accustomed reward system, leading to a sense of restlessness and discomfort

Writing their findings in the Annals of Internal Medicine [1] (online, 15 March 2016), the researchers say: Quitting smoking abruptly is more likely to lead to lasting abstinence than cutting down first, even for smokers who initially prefer to quite by gradual reduction. At four weeks, 39.2% (95% confidence interval [CI], 34.0%44.4%) of smokers who quit gradually were still not smoking, compared with 49.0% (CI, 43.8%54.2%) of smokers in the abrupt group (relative risk, 0.80 [CI, 0.66 to 0.93])

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