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The biological reasoning centers on receptor adaptation

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doi: 10.1111/1523-1747.ep12484041 66 KulskiJKLimCPDunnDSBellgardM

Still early stage, but mechanistically compelling

Updated timeline: May 2026: TRIUMPH-1 Phase 3 topline results announced Late 20262027: Remaining TRIUMPH trials complete

More serious but rare adverse effects include pancreatitis, gallbladder disease, hypoglycemia (when used with insulin or sulfonylureas), acute kidney injury (particularly with dehydration), and hypersensitivity reactions including anaphylaxis