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The following key words and Medical Subject Headings (MeSH) were used either alone or in combination inflammatory bowel, disease, crohn* ulcerative, nicotine tobacco, smoking, smoking cessation, smoking reduction, tobacco use cessation, electronic nicotine delivery systems, tobacco products, smoker*, vaping, cigarette*, steroid*, azathioprine, biologic*, infliximab, thiopurine*, dilatation, tumor, tumour, necrosis factor, mesalamine, 5 ASA, 5 aminosal, relapse*, recurr*, outcome*, remission, relapse*, recurr*, outcome* and remission. The title and abstract for identified studies were evaluated and studies that did not relate to the research questions of interest were excluded

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doi: 10.1038/nri3423 151

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