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Most healthy adults have a heavy store (up to several years worth) of B12 in their liver
By boosting energy levels and reducing fatigue, they may help improve overall activity and exercise performance
Less common: Mild nausea, headache, or temporary fatigue
Stimulants arent your only option
The current public schedule is: TRIUMPH-1: general obesity, 80-week treatment duration, the largest TRIUMPH trial, pivotal for the NDA filing
MTHFR variants like C677T can raise homocysteine and increase demand on the folate and B12 methylation pathway, but they do not by themselves cause deficiency
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