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Furthermore, we found that high SYNCRIP expression was significantly associated with poorer overall survival in patients with GBM, as demonstrated by Kaplan-Meier analysis (Figure S1B)

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These modifications grant it pharmacokinetic properties absent in peptides oral bioavailability, protease resistance, and efficient blood-brain barrier penetration but also mean its metabolic fate and tissue distribution may differ substantially from peptide-class compounds

Administration of a 5 -reductase-2 inhibitor, finasteride, in rats 51 , 52 and monkeys 53 impairs male sexual differentiation and prostate development