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In schizophrenia, immune activation upregulates pro-inflammatory cytokines (e.g., IFN-, IL-1, TNF-), which activate indoleamine 2,3-dioxygenase (IDO) via both IFN- receptor (IFN-R)-dependent and independent pathways (e.g., synergistic action of TLR4, IL-1R, TNF-R) (215)

The clinical trial protocol allowed for dose delays when side effects were intolerable

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However, it is not advisable to use them together as it can lead to serious problems

38 GLP-1RAs increase microvascular blood flow in muscle tissue, enhance myocyte metabolism, inhibit muscle atrophy, and improve muscle mass and function