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1H NMR (DMSO-d 6 ,400MHz)12.89(br1H)7.78(s1H)7.40(m1H)7.08(m 2H)6.91(m2H)6.69(dJ8.8Hz2H)6.24(s1H)4.98(s2H) 4.60(s2H)2.51(qJ8.0Hz2H)1.13(tJ8.0Hz3H)ppm.MS342 (MH + ) Example 1.5: synthesis and characterization of 2- (3, 4-dimethylphenoxy) -N- (1H-pyrazol-3-yl) -N- (thiophen-2-ylmethyl) acetamide (compound 105)

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At each post-operative time point of interest, mice were then euthanized with intraperitoneal injection of pentobarbital

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*Correspondence: Junyu Zhao, [email protected]