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Regional Insights North America Premium Cigarette Market Trends North America maintains a well-established market for premium cigarettes, underpinned by high brand loyalty and mature consumer segments

Strong nicotine pouches contain upwards of 12 mg of nicotine per portion

Not necessarilyboth use the same THCA distillate and can deliver identical potency

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The e-cigarette group exhibited markedly elevated Dyspnoea-12 scores compared to the control group (2.0 vs 0 points, p=0.008), with a moderate effect size (Cohens d=0.52) indicating clinically meaningful respiratory symptom burden