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The hundred trillion microbes and viruses residing in every human body, which outnumber human cells and contribute at least 100 times more genes than those encoded on the human genome (Ley et al., 2006), offer an immense accessory pool for inter-individual genetic variation that has been underestimated and largely unexplored (Savage, 1977

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The importance of this interaction is reflected in the noticeable refractoriness in Wernickes encephalopathy to thiamine treatment alone in hypomagnesemic alcoholics [103]