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North America, while mature, sees the cigarette alternative vaping trend accelerating substitution, making it a bellwether for how regulatory posture shapes long-term tobacco demand

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Surprisingly, castoreum is GRAS (generally recognized as safe) by the FDA and has long been used to enhance artificial versions of raspberry, strawberry and vanilla flavoring, and over the centuries has been added to perfumes to create a leathery aroma

Chang SS, Jiang WW, Smith I, Glazer C, Sun W-Y, Mithani S, et al: Chronic cigarette smoke extract treatment selects for apoptotic dysfunction and mitochondrial mutations in minimally transformed oral keratinocytes

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Because of the similarity, vaping often gets the same treatment