A 32-year-old woman with no prior thyroid history developed painless biphasic thyroiditis (initial hyperthyroidism followed by temporary hypothyroidism) after two months of tirzepatide therapy
While most patients tolerate GLP-1 injections well, common side effects like nausea, vomiting, diarrhea, and constipation tend to improve over time
This is why weight loss is best understood as a downstream effect rather than the first measurable change
You can inject at any time of day, with or without food, so the timing of your weekly injection doesnt need to align with your daily tablet
Anticholinergic medications (some antidepressants, antihistamines, and bladder medications) also reduce GI motility
Conversely, those with lower body weight may feel effects more quickly and more intensely because the concentration relative to their body mass is higher