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Similarly, the SUMO-E3 ligase plays a role in directing nuclear export of SMAD proteins, exacerbating pulmonary fibrosis by enhancing TGF- activity

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doi: 10.1146/annurev-immunol-032414-112220 28 MartinezFOHelmingLGordonS

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[142] [143] Legacy [edit] Perry's portrayal of Chandler Bing on Friends (19942004) became one of television's most recognizable comic performances