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It is also approved for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate-to-advanced liver scarring as well as to lower the risk of heart attack, stroke, and death from heart disease in adults with heart disease and overweight or obesity

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Patients taking antihypertensives (particularly diuretics, alpha-blockers, or nitrates) or SGLT2 inhibitors may experience additive effects on blood pressure or volume status when starting tirzepatide

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