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Redox-homeostasis in the nucleus is maintained by GSH and GSSG exchange with the cytosol via the nuclear pores and by nuclear GR activity (Dorion et al
doi: 10.3390/ijms20081850 [DOI] [PMC free article] [PubMed] [Google Scholar] 47.Jiang X, Jin T, Zhang H, Miao J, Zhao X, Su Y, et al
Tau oligomers bind to cardiolipin, and this binding leads to the creation of membrane pores, causing mitochondrial swelling, cytochrome c release, and a reduction in membrane potential ( Figure 5 illustrates schematically the processes that eventually lead to Alzheimers disease, where the major players are Abeta, phosphorylated tau, and cardiolipin
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