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She soon shared the screen with other Hollywood legends, including Lionel Barrymore, Mickey Rooney and John Wayne (another Iowa native) before she made a lasting impression alongside Jimmy Stewart in Frank Capras 1946 Christmas classic, Its a Wonderful Life. After a few more films playing Hollywoods nice girl, including Faithful in My Fashion (1946), Green Dolphin Street (1947) and Trouble Along the Way (1953), she finally broke typecast

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These alterations contribute to systemic inflammation by increasing the production of pro-inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8, IL-13, tumor necrosis factor-alpha (TNF-), and transforming growth factor-beta 1 (TGF-1) [24]

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