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References Tran KL, Park YI, Pandya S, et al

Upon activation, mast cells rapidly release pruritogenic mediators such as histamine, prostaglandin D 2 (PGD 2 ), tryptase, and -hexosaminidase (Poto et al., 2022), which collectively stimulate C-type sensory nerve fibers and trigger neuroimmune amplification (Siiskonen and Harvima, 2019)

However, GB demonstrated immunosuppressive effects at high dietary levels (4 g GB/kg intake), indicating that its levels in the diet should be optimized [100]

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Mateen, S., Moin, S., Shahzad, S

Phase 3 trials are ongoing, and more comprehensive safety data including detailed reporting of hair-related adverse events are expected to be published in due course