Managing common side effects Nausea: Eat smaller, more frequent meals Avoid fatty, fried, and spicy foods Stay upright after eating (don't lie down) Ginger tea or ginger supplements may help Take anti-nausea medication if prescribed Diarrhea: Stay well-hydrated Consider electrolyte replacement Avoid trigger foods Take OTC anti-diarrheal if persistent Constipation: Increase fiber intake gradually Drink plenty of water Consider stool softeners Light exercise can help Appetite loss (beyond desired effect): Prioritize protein-rich, nutrient-dense foods Eat even when not hungry (small amounts) Consider protein shakes if solid food is difficult When to contact your provider Contact immediately if: Severe abdominal pain Signs of pancreatitis (severe pain radiating to back) Severe vomiting that won't stop Signs of dehydration Allergic reaction (rash, swelling, difficulty breathing) Unusual symptoms not listed here Contact for guidance if: Side effects persist beyond 2 weeks Side effects interfere with daily life You're considering dose adjustment You've missed doses and need guidance For comprehensive safety information, see our peptide safety guide

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Nutr Metab Cardiovasc Dis 2010;20:22435
Patients with advanced, uncontrolled type 2 diabetes on insulin For patients with advanced, uncontrolled type 2 diabetes who were already on insulin therapy, both oral and injection semaglutide showed significant reductions in HbA1c levels
doi:10.1016/S1474-4422(20)30231-3 150
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