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Founded in 2008, the firm was one of the earliest trailblazers of the nascent HNB sector and originally developed devices primarily used to extract vapors from loose-leaf dried herbs and cut tobacco stuffed into a drum-like heating chamber

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An additional 324 articles were excluded at the full-text level (provided in SUPPLEMENTAL SECTION 2: Studies excluded at full-text level screening (with reason for exclusion)), resulting in 135 relevant articles eligible for inclusion

These enzymes kickstart a chain of biological and chemical reactions resulting in the creation of complex molecules, including CBD, as well as its precursors such as cannabigerolic acid (CBGA) and cannabigerovarin acid (CBGVA)