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Patients may need a more careful discussion if they have a history of: Previous NAION in one eye Significant optic nerve crowding Diabetes with vascular complications Sleep apnea, especially untreated sleep apnea High blood pressure or low nighttime blood pressure Cardiovascular disease Sudden unexplained vision loss in the past This does not automatically mean a GLP-1 medication is unsafe, but it does mean the patient should have a personalized risk-benefit discussion with their medical provider

Eslam, Mohammed

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"GLP-1s have been a literal lifesaver for me

Whether the use of higher isradipine dose, or the initiation of treatment with isradipine in even earlier prodromal stages of PD would be more successful is not clear, but better in vivo markers of disease progression and measurement of target engagement are necessary before further studies are undertaken (Maiti et al

There is increasing evidence that mitochondria are important targets for melatonin to exert protective effects under pathological conditions