In the Phase 3 TRIUMPH-4 trial, 33% of participants on the 12 mg dose reported diarrhea compared to 13.4% on placebo (Wang et al., Syst Rev Meta-Analysis, 2025)
Follow Labeling and Shelf-Life Protocols Another important thing to keep in mind while learning about how to store bacteriostatic water after opening is to label the vials properly
Arenbaoligao, Guo X, Xiong J, Zhang S, Yang Y, Chen D, et al
doi: 10.1128/spectrum.04370-22 68 IshikawaH.MatsumotoS.OhashiY.ImaokaA.SetoyamaH.UmesakiY.et al
Ebrahim, N., Shakirova, K
J Cardiovasc Pharmacol 41:880889 Kobayashi A, Kang M-I, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M (2004) Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2