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3 Despite tremendous strides made in raising public awareness regarding the adverse health effects of smoking and the associated risk of lung cancer, smoking cessation remains a challenge both for physicians and patients

The pleiotropic effects of tobacco smoke on the immunostimulatory function of DCs are further illustrated by a study reporting a diminished capacity of DCs from cigarette smoke-exposed mice to induce IL-2 production by T cells, which was associated with a decreased antigen-specific T-cell proliferation in vivo

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