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However, among current smokers, although normalization of testosterone levels also led to a decrease in all-cause mortality, it did not offer any benefit in MI

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The best way to do this would be to take smokers and measure before and after quitting to see if levels recover, though you could more easily do the study in animals by artificially increasing and decreasing levels of cadmium

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Eur J Cancer Care (Engl) , 25 , 231241