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Within a couple of months, he was headlining whole weekends, the likes of Kris Kristofferson were dropping by, Roger Ebert wrote a rave in the Chicago Sun-Times, and soon Prine was signing to Atlantic Records in New York

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"However, a substantial proportion of respondents report having no opinion either way on these policies, suggesting there is potential to grow public support through clearer communication on the evidence and benefits of these policies

Additionally, previous studies have shown that p53 gene polymorphism was significantly related to the incidence of smoking-related COPD, and p53 protein was markedly increased in COPD smokers [150, 151]