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Additionally, upregulation of NOX2 has been shown to enhance the anti-pyroptotic and anti-inflammatory effects of metformin

Thus, the clinical and experimental studies convincingly show the involvement of mitochondrial abnormalities in RS, although the mechanisms underlying the role of mitochondrial dysfunction need further investigation

Gavrilin MA, McAndrew CC, Prather ER, et al

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Gig Harbor, WA: Institute for Functional Medicine

Enhancement of Energy Levels and Reduction of Fatigue: By playing a key role in energy metabolism, a sufficient supply of *B vitamins* can help combat chronic fatigue, boost overall energy levels, and improve vitality