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However, long-term human data is limited, which is why medical assessment and monitoring are essential

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In a cervical cancer cell line (HeLa), the compound reduced cell proliferation in a concentration- and time-dependent way and lowered expression of phospho-Akt and SIRT1, two proteins tied to tumor progression, while a non-cancer reference cell line was less affected

This inhibition causes AICAR to accumulate intracellularly

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8.5 Geriatric Use Reported clinical experience has not identified differences in responses between the elderly and younger patients