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However, there have been some randomized controlled trials examining the efficacy of smoked cannabis for various medical conditions: Cannabis has been shown to relieve chronic neuropathic pain among patients with HIV-associated sensory neuropathy

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In contrast, THC has the potential for addiction in some individuals

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There are also many local jurisdictions across the country that have enacted policies prohibiting or restricting the sale of flavored e-cigarettes, either as part of a more comprehensive policy restricting the sale of flavored tobacco products or as a separate ordinance focused on e-cigarette sales