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PMID 22450609

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Weight trajectory after restarting is also unstudied

Neurologic symptoms may take longer, but many people notice energy/mood improvements within days to weeks once deficiency is corrected

Over-loss and muscle pooled SURMOUNT, BMI below 22 reached by about 7% (as early as week 12), toward about 15% by week 88 in the longest trial, clinical underweight under 0.4% (Almandoz 2026)