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Research indicates that FOXO4-DRI can selectively remove senescent cells in chondrocytes, which are the cells found in cartilage

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Concurrently, damage-associated molecular patterns (DAMPs), such as HMGB1 and mitochondrial DNA, are released from necrotic or apoptotic cells, activating toll-like receptors (TLR4) and NOD-like receptors, thereby promoting inflammation through recruitment of neutrophils and monocytes into the myocardium