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The combination of reduced food intake (and therefore reduced water from food) plus potential gastrointestinal effects means dehydration is a real risk

Effect on hemoglobin A1c (HbA1c) and body weight after discontinuation of tirzepatide, a novel glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist: A single-center case series study

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Mamas MA, Bays H, Li R, Upadhyay N, et al