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Finally, 12 of the 97 publications (12%) were related to studies on biomarkers and biological endpoints in people who use TNPs and showed that smoking cigarettes negatively influenced cardiovascular, respiratory, oral, renal, stress, metabolic, and inflammatory-related biomarkers and physiological assessments

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Furthermore, TDM of clozapine seems to be particularly important for patients who start or stop smoking

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Global Tobacco Market: Dynamics 12