Targeting the high-expression enzymes in cancer amino acid metabolism via small molecule inhibitors or RNAi-targeting approaches is emerging as a crucial therapy (Martinez-Outschoorn et al., 2017
However, as such, they cause a major problem since they may cause severe nutrient deficiencies
In light of the promising evidence regarding the beneficial effects of GLP-1 RAs, their use in diabetic and obese patients has been exponentially growing in the past few years
Zhang C, Shen S, Xu L, Li M, Tian B, Yao L, et al
That includes competitor Novo Nordisk's (NVO) semaglutide, which is also part of Lilly's agreement
Akkermansia muciniphila supplementation has been shown to reduce BP through the reduction of OS markers, likely through increased propionate production, but its translation to the clinic is quite controversial (Lakshmanan et al., 2022)