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Several studies have explored the ability of polyphenols to regulate NF-B signaling and have revealed that they exert repressing effects on NF-B activation through a diversity of mechanisms [194]: - They can inhibit the activity of IKK, thereby preventing the phosphorylation and subsequent degradation of IB proteins

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However, the human cerebellum is easily accessible to non-invasive stimulation due to its anatomical location [195]

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