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Despite decades of awareness campaigns, around one-third of men of reproductive age still smoke traditional cigarettes

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As a direct consequence of a reduction in exposure to carcinogenic toxicants, switching to a cMRTP use should also lead to a significant reduction in urinary genotoxicity (a biomarker of total genotoxic exposure) compared with continued smoking and approach the urinary genotoxicity observed upon smoking abstinence [37]

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