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One of the latest systematic reviews on the topic covered a total of 4 trials and reported significant improvement in the condition, assessed according to a 72-point scale called Psoriasis Area and Severity Index (PASI)

Further investigations are needed to elucidate the molecular mechanisms underlying IGF- 1R-mediated endothelial dysfunction, including oxidative stress [76,77,78], inflammation [30], pathways involved in cellular senescence [17], and metabolic alterations [79, 84, 85]

[DOI] [PubMed] [Google Scholar] 80.Lu V.M., Marek T., Gilder H.E., Puffer R.C., Raghunathan A., Spinner R.J., Daniels D.J

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