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2 Events related to a clinical picture of altered skin sensation such as sensitive skin, hyperesthesia, dysesthesia and paresthesia were reported by a higher proportion of participants, and at a higher rate, in the Wegovy HD arm (22%), compared to treatment with Wegovy 2.4 mg (6%) and placebo (0.3%)

In adipose tissue, the combination of GIP-mediated fat cell signaling with GLP-1-mediated appetite suppression appears to produce metabolic improvements through complementary mechanisms reducing energy intake while simultaneously improving adipose tissue insulin sensitivity

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